2,6-BIS(TRIFLUOROMETHYL)BENZENEBORONIC ACID - Names and Identifiers
Name | 2,6-Bis(trifluoromethyl)benzeneboronic acid
|
Synonyms | 2,6-DITRIFLUOROMETHYLPHENYL BORONIC ACID 2,6-BIS(TRIFLUOROMETHYL)PHENYLBORONIC ACID 2,6-BIS(TRIFLUOROMETHYL)BENZENEBORONIC ACID (2,6-Bis(trifluoromethyl)phenyl)boronicacid 2,6-Bis(trifluoromethyl)benzeneboronic acid [2,6-Bis(trifluoromethyl)phenyl]boronic acid Boronic acid, B-[2,6-bis(trifluoromethyl)phenyl]- boronic acid, B-[2,6-bis(trifluoromethyl)phenyl]-
|
CAS | 681812-07-7
|
InChI | InChI=1/C8H5BF6O2/c10-7(11,12)4-2-1-3-5(8(13,14)15)6(4)9(16)17/h1-3,16-17H |
2,6-BIS(TRIFLUOROMETHYL)BENZENEBORONIC ACID - Physico-chemical Properties
Molecular Formula | C8H5BF6O2
|
Molar Mass | 257.93 |
Density | 1.50±0.1 g/cm3(Predicted) |
Melting Point | 168-171 |
Boling Point | 258.3±50.0 °C(Predicted) |
Flash Point | 110°C |
Water Solubility | Insoluble in water. |
Vapor Presure | 0.00708mmHg at 25°C |
pKa | 7.69±0.58(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.419 |
MDL | MFCD04039321 |
2,6-BIS(TRIFLUOROMETHYL)BENZENEBORONIC ACID - Risk and Safety
Hazard Symbols | Xi - Irritant
|
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin.
R36 - Irritating to the eyes
|
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
|
Hazard Note | Irritant |
2,6-BIS(TRIFLUOROMETHYL)BENZENEBORONIC ACID - Introduction
2,6-Bis(trifluoromethyl)benzeneboronic acid is an organic compound with the chemical formula C8H5BF6. Specific properties are as follows:
Nature:
-Appearance: colorless crystal
-relative molecular mass: 212.93g/mol
-melting point: 114-116 ℃
-Boiling point: 208-210 ℃ (decomposition)
-Solubility: Soluble in organic solvents such as ether and alcohol, insoluble in water
Use:
- 2,6-Bis(trifluoromethyl)benzeneboronic acid is often used as an important reagent and intermediate in organic synthesis.
-It can be used as a ligand in metal coordination chemistry for catalyst synthesis and organic synthesis reactions.
-In the field of medicine, it is also used as an important intermediate in drug synthesis.
Preparation Method:
2,6-Bis(trifluoromethyl)benzeneboronic acid preparation method is more complex, commonly used methods include the following steps:
1. First, phenylboronic acid was prepared by the reaction of boron hydride and iodobenzene.
2. Then, through a deoxidation reaction, phenylboronic acid is converted into bis (dimethylbenzyl) phenylboronic acid.
3. Finally, bis (dimethylbenzyl) phenylboronic acid is converted into 2,6-Bis(trifluoromethyl)benzeneboronic acid through a fluorination reaction.
Safety Information:
When dealing with 2,6-Bis(trifluoromethyl)benzeneboronic acid, you need to pay attention to the following safety precautions:
-Avoid inhalation, ingestion and contact with skin and eyes. Wear protective equipment.
-Good ventilation conditions should be maintained during operation.
-Storage should avoid contact with flammable substances, and stored in a dry, cool place.
-Please dispose of waste and residues properly and comply with relevant laws and regulations.
Last Update:2024-04-09 21:01:54